Ever wondered why some people react badly to cannabis?
Well, researchers have found about one in four people carry a gene that leads to less efficient THC breakdown, which could potentially intensify the drug’s effects.
Additionally, the study found females metabolise THC more slowly and thus face a higher risk of cannabis use disorder (CUD).
Genetic differences
The study, recently published in Addictive Behaviors, sheds light on how differences in THC metabolism, the primary psychoactive component of cannabis, can affect individuals’ reactions to the drug and their susceptibility to CUD.
CUD, which affects about one in five cannabis users, can lead to withdrawal symptoms, cravings, and difficulties in reducing cannabis intake.
This new study suggests that genetic variations in enzymes responsible for THC metabolism may play a crucial role in this susceptibility.
Approximately one in four individuals carries a gene that leads to less efficient THC breakdown, potentially intensifying the drug’s effects.
Novel findings
Dr. Davis emphasised the novelty of their findings, indicating that while similar associations have been observed for other drugs, this is among the first to explore such connections with cannabis.
The study focused on 38 young adults aged 18-25 with CUD and 16 with other substance use disorders. Blood samples were collected to test for gene variants affecting THC metabolism.
Participants also completed questionnaires assessing their experiences with cannabis.
Results revealed sex-specific effects, with females metabolising THC more slowly and thus potentially facing a higher risk of CUD.
Additionally, males with a gene variant linked to slower THC metabolism reported more negative effects after cannabis use, such as drowsiness and difficulty concentrating.
Considering the rise in cannabis potency and the availability of high-potency products, further research is needed to identify and address risk factors for CUD, particularly among vulnerable groups like adolescents.
Understanding how genetic factors influence THC metabolism can make cannabis safer to use and offers insights into personalised treatments for individuals struggling with CUD.
Source: https://pubmed.ncbi.nlm.nih.gov/38394959/
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