The majority of people using CBD do so to treat anxiety. And science is showing that both THC (at very low doses) and CBD have profound anti-depressant effects. In fact, the anxiety-relieving effects of CBD are probaby its most well-studied effect.
If you suffer from anxiety and are considering giving CBD a try, have a look at the following studies on CBD and anxiety. We’ve also included a couple of studies on the endocannabinoids system and the role it plays in mitigating anxiety.
“Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Moreover, CBD was shown to reduce anxiety in patients with social anxiety disorder.”
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
“CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed.”
- CBD reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
“Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech”
“These results suggest that CBD reduces anxiety in SAD and that this is related to its effects on activity in limbic and paralimbic brain areas.”
- Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
“These studies provide further support that eCB-augmentation is a viable pharmacological strategy for the treatment of stress-related neuropsychiatric disorders.”
” These results suggest that CBD has anxiolytic properties, and that these effects are mediated by an action on limbic and paralimbic brain areas.”
- The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1Areceptors
“These results give further support to the proposal that BNST is involved in the anxiolytic-like effects of CBD observed after systemic administration, probably by facilitating local 5-HT1A receptor-mediated neurotransmission.”
- The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
“These findings support that the anxiolytic effect of chronic CBD administration in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signalling.”
“…the eCB system modulates anxiety-related behavior dependent on stressful situations, such as the involvement of different receptors, distinct eCBs, modulation of neurotransmitters release, HPA axis and immune system activation, and plastic mechanisms…”
- CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
“Understanding how cannabidiol regulates emotion and emotional memory processing may eventually lead to its use as a treatment for anxiety-related and substance abuse disorders. ”
- Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats
“…results suggest the anxiolytic effects of CBDA and CBD may require the presence of a specific stressor.”
- Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.
“This case study provides clinical data that support the use of cannabidiol oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.”
“…CBD has minimal behavioral and subjective effects in healthy volunteers, even when they are presented with emotional stimuli.”
– A big thank you to ProjectCBD for curating these links.